Cyproterone acetate is an anti-androgen drug. Adverse effects that have been reported with its use include weight gain, depression, fatigue, breast symptoms and sexual dysfunction.

Does cyproterone have side effects?

tiredness and weakness (fatigue) depression or mood changes. hot flushes or sweats. swelling in parts of the body (fluid build up)

How long does cyproterone last?

CPA is used with ethinylestradiol as a combined birth control pill to prevent pregnancy. This birth control combination has been available since 1978. The formulation is taken once daily for 21 days, followed by a 7-day free interval.

What is cyproterone used for?

Since cyproterone acetate blocks the action of androgens and reduces the amount of androgens produced by the body, it can be used to help relieve the symptoms of a tumour of the prostate gland. It can also be taken by males to control an over active sex drive.

Can you drink alcohol while taking cyproterone?

Alcohol: The effectiveness of cyproterone may be reduced if you consume alcohol. You should limit the amount of alcohol you drink when taking this medication. Depression: Cyproterone use has occasionally been associated with an increased incidence of depressive mood changes, especially with start of therapy.

Hormones and Mental Illness in Women - PMDD / Depression and the Pill / Perimenopausal Depression

41 related questions found

Can cyproterone cause weight gain?

Cyproterone acetate is an anti-androgen drug. Adverse effects that have been reported with its use include weight gain, depression, fatigue, breast symptoms and sexual dysfunction.

What happens when you stop taking cyproterone acetate?

Cyproterone acetate can sometimes change the way the liver functions. If this happens, you will stop taking the drug, and your liver should return to normal. Tell your doctor if you notice any yellowish coloring on your skin or in your eyes.

How does cyproterone block testosterone?

CPA blocks the effects of androgens like testosterone in the body, which it does by preventing them from interacting with their biological target, the androgen receptor (AR), and by reducing their production by the gonads and hence their concentrations in the body.

When is the best time to take cyproterone?

Take your medicine after meals at about the same time each day. Taking it at the same time each day will have the best effect. It will also help you remember when to take it. Missed CYPROTERONE AN tablets may diminish the effectiveness of treatment and may lead to breakthrough bleeding in women.

Is cyproterone better than spironolactone?

On univariate analysis, the cyproterone group had significantly lower total testosterone concentrations (0.8 nmol/L (0.6-1.20)) compared with the spironolactone group (2.0 nmol/L (0.9-9.4), P = 0.037) and oestradiol alone group (10.5 nmol/L (4.9-17.2), P < 0.001), which remained significant (P = 0.005) after ...

Why is cyproterone banned in the US?

Notably, although cyproterone has been used internationally for many years, it is not available in the US due to rare case reports of hepatotoxicity in men receiving high doses for prostate cancer (9).

Does cyproterone acetate stop hair loss?

Recent studies performed by Sinclair show that 200 mg/day spironolactone has an effect equal to 100 mg/day cyproterone acetate, determining in 44% of the cases reduced hair loss and hair regrowth. In 12% of the cases it stops the disease progression [24].

Can cyproterone cause blood clots?

Rarely, CPA can produce blood clots, liver damage, excessively high prolactin levels, prolactinomas, and meningiomas. Upon discontinuation from high doses, CPA can produce adrenal insufficiency as a withdrawal effect.

Does progesterone cause drowsiness?

you should know that progesterone may make you dizzy or drowsy. Do not drive a car or operate machinery until you know how this medication affects you. If progesterone does make you dizzy or drowsy, take your daily dose at bedtime.

Are androgens hormones?

Androgens are hormones that contribute to growth and reproduction in both men and women. Androgens are usually thought of as male hormones, but the female body naturally produces a small amount of androgens too. Androgen deficiency in women is a controversial concept.

Are Antiandrogens safe?

In addition, antiandrogens can cause infertility, osteoporosis, hot flashes, sexual dysfunction (including loss of libido and erectile dysfunction), depression, fatigue, anemia, and decreased semen/ejaculate volume in males. Conversely, the side effects of selective AR antagonists in women are minimal.

What are the side effects of cyproterone acetate and ethinyl estradiol tablets?

What are some common side-effects of this medication?

• Spotting or bleeding may occur between your periods during the first 1-2 months of taking oral contraceptives. ...
• Nausea, vomiting, bloating and stomach cramps.
• Breast tenderness.
• Headache or migraine.
• Intolerance to contact lenses.
• Weight changes, mood swings.

Is cyproterone a progesterone?

Cyproterone acetate is a synthetic progesterone derivative with antiandrogenic and progesterone-like activity used in the treatment of advanced prostate cancer. It is not approved by the FDA for use in the United States but is approved in other countries.

What is the work of cyproterone acetate?

Cyproterone acetate (CPA) 2 mg, combined with ethinylestradiol (EE) 35 μg, is indicated for the treatment of moderate to severe acne related to androgen-sensitivity (with or without seborrhea) and/or hirsutism, in women of reproductive age.

Is progesterone an androgenic?

Progesterone is an anti-androgen because it competes with androgens for androgen receptors and an anti-estrogen because it downregulates estrogen receptors (Johnson and Everitt, 1995).

What is a natural anti-androgen?

Naturally Occurring Anti-Androgens

Red reishi, which has been shown to reduce levels 5-alpha reductase, the enzyme that facilitates conversion of testosterone to dihydrotestosterone (DHT). Licorice, which has phytoestrogen effects and reduces testosterone levels.

Does anti-androgen cause baldness?

An anti-androgen medication can slow down hair loss in men with typical male pattern baldness. Androgens are male sex hormones. Both men and women make androgens, but males typically make much higher levels, which can cause hair loss.

Does cyproterone stop ovulation?

Experiments showed that the ovulation inhibition dose is 1 mg of cyproterone acetate, administered daily. Results proved that the cyproterone acetate dose cannot be reduced when cyproterone acetate is combined with ethinyl estradiol.

Is cyproterone a contraceptive?

Ethinylestradiol/cyproterone acetate (EE/CPA), also known as co-cyprindiol and sold under the brand names Diane and Diane-35 among others, is a combination of ethinylestradiol (EE), an estrogen, and cyproterone acetate (CPA), a progestin and antiandrogen, which is used as a birth control pill to prevent pregnancy in ...

How long until Estelle is effective for skin?

Within a few weeks your skin should not be as greasy and after three months your acne should have started to improve with fewer and fewer new spots appearing. With Estelle-35ED, some women find their skin clears completely and quite quickly. Others find it takes longer.