noun. 1A challenge made in return; a second or repeated challenge. The action of rechallenge ; an instance of this.

What is the meaning of rechallenge?

rechallenged; rechallenging; rechallenges. Definition of rechallenge (Entry 2 of 2) transitive verb. : to challenge again But now a new breed of independent store is beginning to rechallenge the chains and discount online retailers.—

What does rechallenge mean in medical terms?

Rechallenge – This refers to the restarting of the same drug after having stopped it, usually for an AE. Rechallenges may also be complete or partial. Thus the patient may have restarted ampicillin a week later after having stopped it. A positive rechallenge – This refers to the AE recurring after restarting the drug.

What does Tissot mean?

Tissot SA (French pronunciation: ​[ti'so]) is a Swiss luxury watchmaker. ... The company was founded in Le Locle, Switzerland by Charles-Félicien Tissot and his son, Charles-Émile Tissot, in 1853. After several mergers and name changes, the group which Tissot SA belonged to was renamed the Swatch Group in 1998.

What is a rechallenge study?

Challenge–dechallenge–rechallenge (CDR) is a medical testing protocol in which a medicine or drug is administered, withdrawn, then re-administered, while being monitored for adverse effects at each stage.

Dechallenge and Rechallenge in Pharmacovigilance

15 related questions found

What is rechallenge and Dechallenge in pharmacovigilance?

not conclusive indication of drug-induced disease. • In cases where a withdrawal reaction is experienced, a dechallenge is when. the drug is again given to the patient. • “Positive” dechallenge = improvement of reaction when dechallenge occurs. Rechallenge = reintroducing the drug after a dechallenge.

What is pharmacovigilance commonly called?

Pharmacovigilance (PV, or PhV), also known as drug safety, is the pharmacological science relating to the collection, detection, assessment, monitoring, and prevention of adverse effects with pharmaceutical products.

Is powermatic 80 serviceable?

The Swissmatic is essentially a disposable mechanical movement. The Powermatic 80 is derived from the 2824, but it has some "nylon" (plastic) parts in it to help with the longer PR and make it less serviceable.

What does 1000 stand for on the Tissot Seastar 1000?

Let's jump right into it with the meaning of the “1000” in its name – water resistance. Water resistance: This is a dive watch, and it has a water resistance rating of 30 bar, meaning 1000ft or 300m equivalent.

Which is better Seiko or Tissot?

However, the Tissot outperforms. The Tissot Seastar automatic winding watch ensures the watch has 80 hours of reserved power. But the comparable Seiko model, the Seiko Prospex, reserves 41 hours. While both offer excellent reserves, Tissot is the better choice with nearly twice the duration.

What is tumor rechallenge?

A common preclinical method used to document long-term immunity is the use of tumor rechallenge experiments in which tumor growth is assessed in mice that have previously rejected tumors in response to therapy.

Who Naranjo scale?

The Naranjo Algorithm, or Adverse Drug Reaction Probability Scale, is a method by which to assess whether there is a causal relationship between an identified untoward clinical event and a drug using a simple questionnaire to assign probability scores.

What contains Icsr?

For reporting purposes, done electronically in EU/EEA, the ICSR should contain the following 4 basic elements: An identifiable patient/subject; An identifiable reporter, A suspect drug or biological product, An adverse event or fatal outcome.

What is the difference between AE and ADR?

An adverse event (AE) is any negative medical occurrence that is associated with the use of a medication or a medical error. An AE can be life-threatening. An ADR differs from an AE in that an ADR is associated with a causational relationship between the medication and the injury.

What e2a stands for in pharmacovigilance?

Unexpected Adverse Drug Reaction

An adverse reaction, the nature or severity of which is not consistent with the applicable product information (e.g., Investigator's Brochure for an unapproved investigational medicinal product). (See section III.

Is the Tissot Seastar any good?

Tissot Seastar Review: The Verdict

Unfortunately, it doesn't surpass the originals but it sure comes close (and at a significantly cheaper price). Its dial runs a bit large at 43mm, however it has an acceptable thickness. So even though this watch is not the most comfortable watch out there, it is acceptable.

Are Tissot Seastar watches good?

Tissot bills the Seastar 1000 as “an elegant watch for watersport lovers” and, wearing it for a week, we were certainly struck by the jewellery-like quality of this latest iteration. ... It is a watch that everyone will notice, not least because it is 43mm across and sits high on the wrist.

Is Tissot Seastar a divers watch?

The automatic choice for divers. With its high water-resistance up to a pressure of 30 bar (300 m/1000 ft), screw-down crown and caseback as well as its unidirectional ceramic bezel, the Tissot Seastar 1000 is the ultimate diving watch, now combined with the energy of the Powermatic 80 movement.

What is the difference between powermatic and automatic?

An automatic watch is powered by the energy of the person who wears it. ... The Powermatic 80 movement boasts 80 hours of power reserve, which is enough to continue telling time accurately even if the watch is not worn for three days.

Is Tissot a luxury?

Though Tissot is positioned as a luxury watch brand in the mid-price range, with timepieces priced as low as around S$500, it has introduced innovations that even top brands would have been proud of. ... "We launched the first tactile watch 20 years ago, the Tissot T-Touch.

What does powermatic mean?

Tissot is a brand that hardly needs any introduction. ... Among the newest of Tissot's line are a few series of watches that wear the moniker “Powermatic 80” on their dial, which indicates the presence of an 80-hour power reserve movement, specifically the new and exclusive ETA C07.

Who art in pharmacovigilance means?

The WHO Adverse Reactions Terminology (WHOART) is a dictionary meant to serve as a basis for rational coding of adverse reaction terms. The system is maintained by the Uppsala Monitoring Centre (UMC), the World Health Organization Collaborating Centre for International Drug Monitoring.

Is pharmacovigilance a part of clinical research?

Pharmacovigilance begins with clinical trials that provide data on the benefits and risks of a drug. The aim of pharmacovigilance in clinical research is to determine if the benefits outweigh the risks; if they do, drug manufacturers take steps to gain approval to market the new drug.

What is meant by AE in pharmacovigilance?

Description. Adverse event (AE) (largely considered synonymous with adverse experience) Any untoward medical occurrence in a patient or clinical investigation subject administered a pharmaceutical product and which does not necessarily have to have a causal relationship with this treatment.