Hydrophilic doxorubicin hydrochloride (DOX·HCl) or hydrophobic doxorubicin base (DOX) were encapsulated into these polymersomes with high payload and high encapsulation efficiency due to the strong intermolecular interaction with polyphosphazene chain [529].

Is doxorubicin water soluble?

Researchers have also demonstrated that doxorubicin effectively inhibits human DNA topoisomerase I (5). Solubility: Soluble in DMSO at 100 mg/ml; very poorly soluble in ethanol; soluble in water at 10 mg/ml with slight warming. Directions for Use: Doxorubicin is supplied as a lyophilized powder.

How do you dissolve doxorubicin?

For maximum solubility in aqueous buffers, doxorubicin (hydrochloride) should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. Doxorubicin (hydrochloride) has a solubility of approximately 0.5 mg/ml in a 1:1 solution of DMSO:PBS (pH 7.2) using this method.

What is Adriamycin used for?

Adriamycin PFS (doxorubicin hydrochloride) Injection is a cancer (antineoplastic) medication used to treat many types of cancer.

Why does H stand for doxorubicin?

Each letter in R-CHOP stands for a different drug, but the acronym can be confusing in that a single drug sometimes has more than one name: R = Rituximab. C = Cyclophosphamide. H = Doxorubicin Hydrochloride (Hydroxydaunomycin)

Hydrophilic vs Hydrophobic | Substances | Cell Membranes

29 related questions found

What is doxorubicin for?

Doxorubicin is used in combination with other medications to treat certain types of bladder, breast, lung, stomach, and ovarian cancer; Hodgkin's lymphoma (Hodgkin's disease) and non-Hodgkin's lymphoma (cancer that begins in the cells of the immune system); and certain types of leukemia (cancer of the white blood cells ...

How do you make a doxorubicin solution?

Intravesical administration:

The recommended doxorubicin hydrochloride dose for local intravesical treatment of superficial bladder tumors is instillation of 30-50 mg in 25-50 ml of sodium chloride 9 mg/ml (0.9%) solution for injection. The optimal concentration is about 1 mg/ml.

Is anthracycline an antibiotic?

A type of antibiotic that comes from certain types of Streptomyces bacteria. Anthracyclines are used to treat many types of cancer. Anthracyclines damage the DNA in cancer cells, causing them to die.

What is doxorubicin soluble?

Doxorubicin hydrochloride is readily soluble in water, slightly soluble in normal saline, and sparingly soluble in alcohol. After reconstitution the solution is orange-red at neutral pH and is stable for 1 month at 5° C.

Is doxorubicin charged?

Sounds that DOX(HCL) has the 0 formal charge which is calculated by PubChem.

Is doxorubicin a fluorescent?

Doxorubicin has intrinsic fluorescence which serves as a valuable tool in research and imaging [2–5,10]. It has an emission signal at 595 nm upon excitation with a 470 nm laser. Binding of Doxorubicin with the cell results in the production of active oxygen species, especially hydroxyl radicals.

Can you freeze doxorubicin?

Doxorubicin hydrochloride, when reconstituted with sterile water for injection, may be refrigerated for six months or frozen for one month without loss of potency.

Is doxorubicin an anthracycline?

Doxorubicin is an anthracycline class medication used to manage and treat various types of malignancies and tumors. This activity will highlight the mechanism of action, adverse event profile, and other factors, including off-label uses, dosing, pharmacodynamics, pharmacokinetics, monitoring, and relevant interactions.

Is carboplatin an anthracycline?

Paclitaxel coupled with carboplatin provides an alternative therapeutic option for anthracycline-exposed patients and warrants further clinical research in the direction of anthracycline-free management of metastatic breast cancer.

Is paclitaxel an anthracycline?

Anthracyclines for Breast Cancer?

What is the mechanism of action of doxorubicin?

Doxorubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Doxorubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation- ...

How does doxorubicin hydrochloride work?

How doxorubicin works. Doxorubicin is a type of chemotherapy drug called an anthracycline. It slows or stops the growth of cancer cells by blocking an enzyme called topo isomerase 2. Cancer cells need this enzyme to divide and grow.

What are the long term effects of doxorubicin?

One notable example is heart damage following treatment with Adriamycin (doxorubicin). With this drug, a possible long-term side effect is weakening of the heart muscle, resulting in a decreased ability to pump blood through the body (heart failure).

What is doxorubicin toxicity?

While an effective anti-tumor agent, doxorubicin causes cumulative and dose-dependent cardiotoxicity, ranging from occult changes in myocardial structure and function to severe cardiomyopathy and congestive heart failure that may result in cardiac transplantation or death^1,2,3,4,5,6.

What is another name for doxorubicin?

Doxorubicin is the generic name for the trade name drug, Adriamycin®, as well as, Rubex®. In some cases health care professionals may use the trade names Adriamycin® or Rubex® when referring to the generic drug name Doxorubicin.

Is doxorubicin a prodrug?

A new prodrug of doxorubicin (DOX-PCB) is described that can be converted to the active drug upon exposure to UV at 350 nm. It was formed by conjugating a photocleavable blocking group to the sugar amine group of DOX.

Is Adriamycin an anthracycline?

Anthracycline chemotherapy medicines are: Adriamycin (chemical name: doxorubicin) Ellence (chemical name: epirubicin)

What is anthracycline and taxane?

Background: Anthracyclines and taxanes are chemotherapeutic agents widely used in a sequential regimen in the adjuvant and neoadjuvant treatment of early breast cancer to reduce the risk of cancer recurrence. Standard practice is to administer anthracycline-based chemotherapy followed by a taxane.

What class is anthracycline in?

Anthracyclines are a class of potent and widely used cytotoxic drugs, derived from antibiotics that inhibit DNA and RNA synthesis by intercalating between base pairs of the DNA/RNA strand. They create iron-mediated free oxygen radicals, damaging the DNA and cell membranes, and inhibit topoisomerase II.

Is DOX a fluorescent?

The typical fluorescence spectra of Dox are shown, with peaks at 560 and 590 nm, with most intense peak at 590 nm. ...